Losing either of the YREs resulted in less YB 1 binding compared with the wild type EGFR promoter sequence Figure 5d <a href=https://nolvadex.one/>tamoxifen weight loss</a> For instance, acetylation at Lys 66 or Lys 268 increases DNA binding in ER alpha, and switching either of these residues with glutamine increases the 17beta estradiol activity of the receptor